Hepatocyte growth factor: A novel tumor marker for breast cancer
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چکیده
منابع مشابه
Hepatocyte growth factor as a tumor marker in the serum of patients with prostate cancer.
BACKGROUND AND AIM Prostate cancer is a leading cause of death among men worldwide; it is invasive and metastasizes to different organs. Metastatic spread of this type of cancer is the greatest barrier to achieve cure. The present study is carried out to study the serum levels of hepatocyte growth factor (HGF) in patients with prostate cancer in relation to stage and grade and to evaluate its d...
متن کاملHepatocyte growth factor promotes tumor growth in a novel in vivo model of human lung cancer.
Significant progress has been made toward identifying growth factors that display autocrine or paracrine effects on the growth of lung cancer cells. Determining the in vivo relevance of specific growth factors on lung tumor formation, however, has not often been demonstrated in laboratory models. Although hepatocyte growth factor (HGF) has been shown to have mitogenic and motogenic effects on h...
متن کاملSerum concentrations of hepatocyte growth factor in breast cancer patients.
Hepatocyte growth factor (HGF) was first identified as a potent stimulator of hepatocyte growth and DNA synthesis. Later, it was shown that HGF can promote cell motility and cell proliferation in various types of cells, including tumor cells and endothelial cells. We have examined serum concentrations of HGF in breast cancer patients using an ELISA. Of 134 primary breast cancer patients, 49 (36...
متن کاملThe hepatocyte growth factor regulatory factors in human breast cancer.
PURPOSE Hepatocyte growth factor (HGF) stimulates tumor cell-cell interactions, matrix adhesion, migration, invasion, and angiogenesis. This factor is produced as an inactive precursor called pro-HGF, which requires proteolytic conversion, by HGF activator (HGFA) and matriptase, to evoke a biological response. Two new HGFA inhibitors, HAI-1 and HAI-2, inhibit the generation of biologically acti...
متن کاملBreast Cancer Cells Induce Cancer-Associated Fibroblasts to Secrete Hepatocyte Growth Factor to Enhance Breast Tumorigenesis
It has been well documented that microenvironment consisting of stroma affects breast cancer progression. However, the mechanisms by which cancer cells and fibroblasts, the major cell type in stroma, interact with each other during tumor development remains to be elucidated. Here, we show that the human cancer-associated fibroblasts (CAFs) had higher activity in enhancing breast tumorigenecity ...
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ژورنال
عنوان ژورنال: Journal of Cancer Research and Therapeutics
سال: 2018
ISSN: 0973-1482
DOI: 10.4103/jcrt.jcrt_1084_16